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As a Death Knight, you'll have six "runes" shown below your health bar. You will have two Blood, Frost, and Unholy runes. Abilities will use a set number of runes that when used will make that number of runes go inactive for 10 seconds until they're recharged. So let's say you're giving a Murloc quite a bit of a thrashing and you use an ability which costs one Blood and one Frost rune. For ten seconds one of the two Blood and Frost runes will be unable to be used. So if you had an ability that used two Blood runes then you'd be out of luck.
You may pay close attention to mana, energy, or rage when you're first leveling up. You needed to carefully watch how much mana you used or else you'd be out and either being chomped on by nasty monsters, watch how much energy you had before you used an ability or else you'd be cutting yourself short on your next ability, or monitor your rage and make sure you were getting enough to use your abilities. Runes and Runic Power work differently than either of these three.
It is undeniable that some abilities can affect the recharge on runes or even convert them into "Death" runes which will work for any of the three rune types. Mixing these abilities into combat can really help you finish off enemies faster and show Murlocs an extra good trashing.
